![]() While the inhibitor of HDLBP has been reported, our work suggested a promising potential of targeting HDLBP to improve the treatment of fatal SCLC and a powerful tool of using cell-SELEX in cancer medicine.Īptamer Cell cycle HDLBP Small cell lung cancer Targeted therapy.Ĭopyright © 2019. Mechanism study revealed the new function of HDLBP in promoting G1/S cell cycle transition for tumor progression. Attenuating HDLBP expression with siRNA inhibited proliferation and metastasis of SCLC cells in vitro and tumor formation in vivo. PMID: 31233742 DOI: 10.1016/j.yexcr.2019.06.023 Abstract Small cell lung cancer (SCLC) has been a recalcitrant cancer without significant breakthroughs in clinical treatment during the past three decades. Immunohistochemistry results showed an elevated HDLBP level in SCLC tissues from clinical samples. Here we identified a new protein biomarker of SCLC, which is high density lipoprotein binding protein (HDLBP), through the aptamer generated by cell-SELEX against SCLC cells. As there is a lack of effective protein inhibitor for SCLC targeted therapy, the discovery of new druggable SCLC biomarkers is a pressing work. Electronic address: cell lung cancer (SCLC) has been a recalcitrant cancer without significant breakthroughs in clinical treatment during the past three decades. ![]()
0 Comments
![]() The only whites in the crowd, they no doubt stood out. King at a Beaumont club called the Raven. There’s a famous story about a time in 1962 when Johnny and his brother went to see B.B. Clarence, who recorded for the swamp boogie specialty label Goldband, KRCO, Frolic, Diamond, Moon-Lite, Hall-Way and other regional labels. Who opened Winter’s eye’s and ears to rural blues and Cajun music. I always felt welcome.” He also became friends with Clarence Garlow, a deejay at the black radio station KJET in Beaumont. I went to black clubs all the time, and nobody ever bothered me. Looking back, he believes people in the black community knew that he was sincere, that he was genuinely possessed by the blues. ![]() Despite the brutal legacy, Johnny remembers never hesitating as a kid to venture into black neighborhoods to hear and play music. ![]() Mobs wandered the streets, businesses burned, martial law went into effect, and more than 2,000 uniformed National Guardsmen and Texas Rangers sealed off the town from the rest of the world until tempers cooled. The town had been side to one of the worst race riots in Texas history just nine months before Johnny’s birth. Racial tensions in Beaumont were still high in those days. He formed his first band, Johnny and the Jammers, in 1959 at the age of 15, with his 12-year-old brother Edgar on keyboards. Richardson – The Big Bopper of “Chantilly Lace” fame – and became hooked on 50’s rock & roll. Growing up in a rough-and-tumble town populated by oilfield wildcatters and shipyard workers, he spent long hours listening to a local deejay named J.P. Constantly shifting between simple country blues in the vein of Robert Johnson, to all-out electric slide guitar blues-rock, – Johnny has always been one of the most respected singers and guitar players in rock and the clear link between British blues-rock and American Southern rock (a la the Allman Brothers and Lynyrd Skynyrd.) Throughout the ’70s and ’80s, Johnny was the unofficial torch-bearer for the blues, championing and aiding the careers of his idols like Muddy Waters and John Lee Hooker. Signing to Columbia records in 1969 called largest solo artist deal of it’s time, Johnny immediately laid out the blueprint for his fresh take on classic blues a prime combination for the legions of fans just discovering the blues via the likes of Jimmy Page and Eric Clapton. Writing in Rolling Stone magazine, after Winter’s death, David Marchese said, “Winter was one of the first blues rock guitar virtuosos, releasing a string of popular and fiery albums in the late Sixties and early Seventies, becoming an arena-level concert draw in the process” … “made an iconic life for himself by playing the blues”.Has been a guitar hero without equal. He was found dead in his hotel room two days after his last performance. Johnny Winter was professionally active until the time of his death near Zürich, Switzerland, on July 16, 2014. In 2003, he was ranked 63rd in Rolling Stone magazine’s list of the “100 Greatest Guitarists of All Time”. In 1988, he was inducted into the Blues Hall of Fame, the first non-African-American performer to be inducted into the Hall. In 1980, Winter was on the cover of the first issue of Guitar World. King International Artist of The Year Award. At the 18th Maple Blues Awards in 2015, Winter was also posthumously awarded the B.B. The album also won the 2015 Blues Music Award for Best Rock Blues Album. In 2015 Johnny Winter posthumously won the Grammy Award for Best Blues Album for Step Back. Several of Winter’s own albums were nominated for Grammy Awards – Guitar Slinger (1984) and Serious Business (1985) for Best Traditional Blues Album, and Let Me In (1991) and I’m a Bluesman (2004) for Best Contemporary Blues Album. ![]() Johnny Winter produced three Grammy Award-winning albums by Muddy Waters – Hard Again (1977), I’m Ready (1978), and Muddy “Mississippi” Waters – Live (1979). HEY LOCO FANS – Happy Birthday to Texas Blues Legend Johnny Winter who was born this day in 1944! Winter was best known for his high-energy blues rock albums and live performances in the late 1960s and 1970s. Today I'm pleased to confirm the list of supported controllers and wheels for the PC version GRID 2: PC Controllers Xbo. Powered by Codemasters’ EGO Game Technology Platform for jaw-dropping damage and stunning visuals, GRID 2 sets the standard for technical excellent in racing. 2 Drive srv180375 View artwork Supported Wheels and Controllers Since we first announced GRID 2 one of the most common questions from our fans has been 'will my wheel be supported'.An extensive and separate online campaign redefines multiplayer racing games plus full RaceNet integration.Blaze your way to the top of a new world of motorsport.Prove yourself against advanced AI in aggressive, blockbuster races packed with wow moments.The race comes alive with GRID 2’s TrueFeel™ Handling system for edge-of-control exhilaration.GRID 2 will also set the new standard for multiplayer racing with innovative modes, an entirely separate progression system and deep integration with RaceNet, the free online extension for Codemasters Racing games. Earn fame, fans and fortune as you blaze your way to the top in intense, relentless races on licensed circuits, beautifully realised city streets and lethal mountain roads. The next generation of the EGO Game Technology Platform delivers genre-defining visuals and jaw-dropping damage as you prove yourself across three continents in a new, evolving world of motorsport. ![]() There are frequent frame rate drops on all maps (1070, 6700K) and the quality of the maps is somewhat lackluster. May someone share its completed save game The save games I downloaded from the Internet seems all 'corrupt' for this version. Ive already played it on XBOX and just dont want to play it all again to access the extra content of the DLCs. Experience aggressive racing against advanced AI and become immersed in the race with GRID 2’s new TrueFeel™ Handling system which powers edge of control exhilaration behind the wheel of every iconic car. Grid 2 Reloaded Edition Call of Duty Infinite Warfare Free Download Repacklab The Call of Duty Twitter account announced both the Xbox One and PC DLC date and it has been a few days since the launch of the DLC. Hello, I just bought Grid 2 Reloaded Edition on Steam. Be fast, be first and be famous as the race returns in GRID 2, the sequel to the BAFTA-award winning, multi-million selling Race Driver: GRID. ![]() How to Send Money Using the Messages App on Your iPhone Someone Just Hacked a Way to Use iMessage on Android How to Send a Friend a Map to Your Current Location or Let Them Track You While Movingįilter Unknown Senders in iMessage to Block Unwanted Notifications & Keep Your Messages App Clean Secretly Send Text Messages in Class or at Work Without Touching Your iPhoneĨ Great New Messages Features in iOS 11 for iPhone Make Texts & iMessages Stand Out on Your iPhone with Bold Subject Lines Google Is Taking on Apple's iMessage with RCS - Here's How Android's New Texting Experience Stacks Up Organize Messages on Your iPhone by Grouping Threads Together into Specific Categories Like Family & Work How to Turn iMessage Read Receipts On/Off Per Person Give Group Messages Custom Names in iOS 8 How to Enable & Disable Read Receipts for iMessages Receive Notifications When Your Name Is Mentioned in Messages Get Text Sounds & Vibration Alerts for Specific Contacts in 'Do Not Disturb' Mode How to Hide Alerts for Specific Conversation Threads ![]() How to Leave Group Conversations on Your iPhone On the next screen, tap on "Enter a Group Name" at the top and do just that (if you're on an older iOS version, you may have to pull down from the top of the screen first to see this option). To give a group conversation a custom name, just open the conversation thread in Messages, then tap either the "i" (info) button or "Details" button in the top right, depending on your iOS version. Also, custom group names only work in iOS 8 or higher for iPad, iPhone, or iPod touch.ĭon't Miss: 8 Great New Messages Features in iOS 11 for iPhone If it's a group message that includes at least one person using SMS or MMS instead of iMessage, such as an Android user, you will not be able to name the group conversation. That's where custom group names come in, which helps you make sense of all those disorganized threads with multiple names/numbers attached.īefore diving into creating new group names in Apple's Messages app, you should know that this only works for group iMessages. However, things can get disorderly real fast in the Messages app, especially if the same person is in multiple group conversations. Group messages are great when you want to talk to multiple people at the same time. ![]() Latte is very popular because the coffee content is very diluted, and the recipe can be tweaked by adding various flavorings, making latte a dessert. Latte is nothing else than milk with coffee, and it originates in Italy, where it is called café latte. These machines have a milk steamer and a 9 bar pump and they are decently reliable. If you want to get the authentic taste, you will need to have the proper equipment, and you can buy a cheap espresso machine, if your budget is limited. The steam want injects air into the milk while heating it, and depending on the amount of air incorporated we can have milk that has a different mouthfeel, and will change the taste of your final espresso drink. The authentic espresso taste can only be produced by pump driven espresso machines.Īlso the steam wand of an espresso machine is the proper tool to texturize milk properly. However, for an authentic cappuccino, real espresso is the best choice. People use various recipes for lattes because the amount of milk sometimes covers the coffee taste. Yes, lattes and cappuccinos are made with an espresso machine. We have a post where we explain what is espresso and another post where we show how is espresso different from regular coffee. But know that the taste will be different. However, you can make your latte at home using cheaper equipment, if you want to ditch your barista. This is what you are buying from a coffee shop. Very similar to a cappuccino, but the milk is micro-foamed and it doesn’t have the dry foam top.Ĭan You Make Latte and Cappuccino at Home?Įspresso drinks are usually made using an espresso machine, which is the traditional method. This is a milk-based drink with just a little coffee.Ģ/5 espresso, 2/5 chocolate, 1/5 steamed milk The espresso is toned down with milk, but the coffee taste is still featured.ġ/6 espresso, 4/6 steamed milk, 1/6 foamed milk Here are the major differences between latte, cappuccino, flat white and mocha: Drinkġ/3 espresso, 1/3 steamed milk, 1/3 foamed milk Cappuccino vs Flat White, vs Latte vs Mocha Caffeinated beverages such as latte, mocha, and cappuccino are also a great way to break the daily coffee routine or to be served at parties.Īlso, the intense coffee flavor of an espresso is not something that every coffee lover enjoys, so coffee drinkers add a little milk to espresso to make it palatable. Why Are Espresso Drinks Popular?Įspresso and milk-based drinks are great for people with a sensitive stomach because the milk tones down the coffee. Note that the microfoam and steamed milk are sometimes confused, even in barista circles. Microfoam milk is steamed but with the purpose to incorporate air in it in a way that keeps it fluid enough.Steamed milk is heated with the steaming wand, but the purpose is just to get warm milk, and not to texturize it.Frothed milk is foamy, and contains mostly air.The main types of textured milk are frothed milk, steamed milk, microfoamed milk, and scalded milk. ![]() In addition to sending person-to-person messages, PyBitmessage allows s to send items to “subscribers” or people who follow their PyBitmessage address. When everything looks good, click the “submit” button. Instead, you’ll need to click the “From” box and select your address when it appears in the menu. PyBitmessage will not automatically use your address in the “From” section. To determine when your message will expire, drag the slider next to “TTL.” Note: PyBitmessage sends disposable messages. Once you have it, click on “Send regular message”. Need to send a Bitmessage to a friend? First, get your Bitmessage address. Instead, it opens the message dialog, where s can compose new things to send. Clicking “send” doesn’t automatically send anything. To send a message with PyBitmessage, click the “Send” button. Shortly after setup, PyBitmessage will display a notification in the system tray saying “connected”. Leave the default settings and click “OK” to begin. Once it’s open, click on the “new identity” button. To start communicating with PyBitmessage, you will first need to create a new identity. Python setup.py install – Using PyBitmessage Note that if you go this route, PyBitmessage will need to be reinstalled multiple times for each who needs to use it. Install PyBitmessage system-wide by running this command as root:Īlternatively, install PyBitmessage as a normal, run the following command. The only important file here is setup.py, as it will take the code, compile it, and put it in the correct location. These files are essential to the program in general, but we can ignore them. Inside the PyBitmessage folder, there are several files. Use the CD command to move the terminal to the newly cloned PyBitmessage folder on your Linux PC. With all the dependencies installed, it’s time to start working with the source code.įirst, using the git tool, clone the latest version of the PyBitmessage source code from GitHub. Most operating systems have instructions inside the checkdeps.py script, including ! building Read the output of the script as it will detect what operating system you have and print the exact packages you need. Git clone cd ~/PyBitmessage python checkdeps.py If you are trying to run this program on an operating system not listed above, follow these instructions to determine what you need. PyBitmessage has a useful script that allows s to scan their operating system and find out what dependencies they need to run the program. To fix this problem, you will need to go to the PyBitmessage AUR page and install the rest of the dependencies manually. If makepkg is not built, you might have some dependencies that cannot be installed automatically. The next step in the process is clone the latest PyBitmessage pkgbuild snapshot.ĬD into the newly cloned pybitmessage directory to start the package build process.Ĭreating packages from the AUR is a quick and easy process. To start installing PyBitmessage on your Arch Linux PC, you’ll first need to install the latest version of the Git package management tool with Pacman package manager. All dependency files are managed automatically. However, given how the AUR works, Arch s get a much cleaner and more automated build process. Installing PyBitmessage on Arch Linux is not much different than building it on other Linux distributions, as we have described in this article. Sudo zypper install python-qt python-msgpack-python python-setuptools gcc-c++ libopenssl-devel python-devel git ArchLinux Sudo dnf install PyQt4 python2-msgpack python2-pyopencl python2-setuptools gcc-c++ redhat-rpm-config python-devel openssl-devel git OpenSUSE Sudo apt-get python-qt4 python-msgpack python-pyopencl python-setuptools build-essential libssl-dev git fedora Sudo apt install python-qt4 python-msgpack python-pyopencl python-setuptools build-essential libssl-dev git Debian To start the build process, open a terminal and install the various libraries and dependency files required for your operating system. ![]() ![]() Fortunately, this program is easy to compile and build from source code. PyBitmessage is an interesting program, but it doesn’t seem like the major Linux distributions have enough interest in it to officially it. Best of all, this program can be used on various operating systems, including Linux! Install PyBitmessage ![]() With this program, s can send P2P messages with the Bitcoin blockchain, securely. One program that takes advantage of this technology is PyBitmessage. There are few things as fascinating as blockchain technology. ![]() Do not install free applications from unreliable websites.But fortunately, this can be stopped by keeping in mind the below mentioned things: How to Prevent CompatTelRunner.exe Virus?Īs discussed already, the CompatTelRunner.exe file is vulnerable to virus and malware infections. exe files including CompatTelRunner.exe will give rise to various kinds of errors. Most often viruses and malwares are disguised as CompatTelRunner.exe and distributed through various medium including emails. Contrary to that, CompatTelRunner is actually a safe and legit file of the Windows system. The fact that this process uses a high amount of CPU resources might exhibit it as a virus or malicious file. However, the file may get affected to malware and virus infections. Collects program telemetry information (if that option is selected) for the Microsoft Customer Experience Improvement Program.Īlso Read: What Is Windows Modules Installer WorkerĬompatTelRunner.exe is essentially not a virus! It is a verified process signed by Microsoft.To upgrade your Windows OS to the latest version.To perform System diagnostics and determine if there are any compatibility issue.Some of the many functions of this file are as mentioned below Created by Microsoft, it is an integral part of the Windows System. This file has some legit functions in the Windows Operating System. It is introduced by Microsoft and is a integral part of the latest windows versions. Functions of CompatTelRunner.exeĬompatTelRunner.exe file or process is responsible for upgradation of the Windows OS to the latest version. Let’s check some of the important functions of CompatTelRunner.exe in Windows OS. Moreover its primary function is to keep Windows updated along with analyzing the use of Windows and helping in its improvement. With Microsoft Compatibility Telemetry, the company gathers information from all the computer and combines these information to improve the services of Windows and enhance the user experience as well as make the OS secured. ![]() And, as a part of it, the company has introduced the compatibility telemetry in most of the Windows versions. Microsoft has always invested a lot in enhancing the user experience. It is process responsible for upgradation of the Windows OS This article is a part of our Windows explanatory series which explains different process found in Windows like msvcp140.dll, msvbvm50.dll, ctfmon.exe, Vulkan Run-time Libraries and many more.ģ Verdict What Is Microsoft Compatibility Telemetry? File Name CompatTelRunner.exe is a system file and an important part of Windows and is located in the C:\Windows\System32 folder. Also known as Windows Compatibility Telemetry, this file or process sends periodical usage and performance data so that user experience is enhanced and some potential errors are rectified. Well, like other jobs in Windows, for the purpose of upgrading the OS, there is a specific file called the CompatTelRunner.exe. You must be wondering, which file or process in the Windows OS is responsible for upgrading and updating the operating system. For example, Microsoft has released the latest version of Windows which is Windows 10 and so most PCs run on Windows 10, unless you are an ardent fan of the earlier versions of Windows. ![]() OS vendors frequently releases newer version of their product in order to reap the full benefits of the OS, it is mandatory to update or upgrade it. In most cases the operating system that is running on your computer might not be the latest one. It is responsible for upgradation of the Windows OS to the latest version. Created by Microsoft, CompatTelRunner.exe is an integral part of the Windows System. The statement is divided into three sections corresponding to the three types of cash flow: operating, investing, and financing.Īnalyzing the cash flow statement enables businesses to understand their cash position, identify trends, and make informed financial decisions. The cash flow statement is a financial report that provides a detailed overview of a company's cash inflows and outflows during a specific period. Examples include issuing or repurchasing shares, borrowing funds, and repaying loans.įinancing cash flow can impact a company's cash position and its ability to fund operations and growth. Financing Cash Flowįinancing cash flow involves cash transactions between a business and its owners, investors, and creditors. ![]() Investing cash flow results from the purchase and sale of long-term assets, such as property, equipment, and investments.Ī positive investing cash flow signifies that a business is disposing of its long-term assets, while a negative investing cash flow indicates that a company is investing in its future growth. It is an essential indicator of a company's ability to generate sufficient cash to maintain and grow its operations. Operating cash flow refers to the cash generated from the core operations of a business, such as sales revenue and payments for goods and services. There are three main types of cash flow that businesses should consider when managing their finances: Operating Cash Flow ![]() Understanding Cash Flow Types of Cash Flow It is a critical aspect of financial management that helps businesses maintain solvency, ensure smooth operations, and support growth.Įffective cash flow management involves understanding key components, including cash inflows, cash outflows, and available cash balances, and implementing strategies to improve the overall financial health of a business. Cash flow management is the process of monitoring, analyzing, and optimizing the inflow and outflow of cash within a business. ![]() Below the Pope is the King, which would be an anime like Tokyo Ghoul. It is FAR from the perfect anime, but more than good enough to qualify as the top of this dung heap sub-genre of anime. It has very obvious flaws, but also has areas where it is rather objectively excellent. At least some of the gore was justified by its artistic intention of tackling humanity's darkness and eternal struggle with the redeeming aspects of the human soul. It overuses nudity and gore, but actually the majority of the nudity was not intended as fanservice. At the top of the Hierarchy is the Pope, which would be Elfen Lied. I feel I need to explain what I mean by this, so let's rank gore and tits exploitation anime as if they were the Medieval European societal hierarchy. Unfortunately, Kite is an entirely different caliber of schlock. Younger fans that haven't seen Kite would be forgiven for thinking Kite is like the early 2000s anime Gantz and The anime Kite was a 1990s hentai/ action exploitation anime that somehow gained a cult following in the US for its over the top use of sex and violence. ![]() ![]() How do you follow what is quite arguably one of the worst anime ever made? With a sequel that is even worse! This is one of those anime that is not only bad, but has absolutely no reason to exist in the first place!īefore we talk about Kite 2, we unfortunately have to talk about Kite. Overall, I would have to say that whether or not you've seen the first film, this is something interesting in its own right and it something well worth watching even with some of the issues that exist within it. ![]() The only problem I had was that story didn't fully explain some of the character details and I was sometimes left wondering about a particular part of certain characters' backgrounds. The main character really kind of reminds you in a lot of ways of Sawa from the first film. The stereo effects were really accurate and made listening to the movie through headphones much more enjoyable than through standard speakers.Ĭharacters: I felt you could empathise with the characters in the story quite well in a similar way as you could for the first movie albeit for different reasons. The themes worked well with the scenes throughout and the sound effects and timing were spot on. Sound: Another case of 'doing what it says on the tin'. Everything was well-rendered or accurately drawn and this component stood out justifyably, fully deserving the 10. The combination of computer graphics as well as more traditional constructions made it very pleasing on the eye. The story element is something that most people will have differing views on but I think 7 is a fair score for this component.Īrt: Well, I have to say that this was one of the standout features of the OVA. At least with Kite you could imagine the events happening in real life. In it's own right, the sci-fi plot is quite entertaining but I was disappointed with massive leap in terms of content from the gritty original to something completely fictional. Even though it is only an hour long in length, the way the plot is constructed makes it feel like a full-length movie. might say that the absence of sex scenes makes the anime not seem like a true sequel and I would have to agree to some extent, but I feel that to do a sequel too similar to the original would have inevitably not have been as good. Whilst the original focused on a gritty underworld story of corruption and violence (which featured nudity), Kite Liberator takes a completely different tact and focuses more on a kind of action-based sci-fi plot. Story: First off I'll start by saying that I thought it was very interesting that they made a non-hentai sequel to a hentai-pigeonholed movie. But as you can see from the ratings I'm part of the contingent that liked it. Well, this is a tricky one to review as it's something that most people will have mixed feelings about as the original Kite was a very interesting work in its own right. ![]() The spectacular features songs and stories of some of the most courageous, loving and inspiring characters, music and moments from Walt Disney Animation Studios, Pixar Animation Studios, the Avengers, and Star Wars.World of Color – ONE celebrates how a single action, like a drop of water, creates a ripple that can grow into a wave of change. If you have obtained a virtual queue selection, enter your designated viewing area for your designated show time via one of the two marked entrance points (Blue or Yellow) approximately 30-45 minutes before the show begins.On nights when there are multiple showtimes, distribution for additional showtimes will begin immediately after distribution for the first showtime has ended. A minute before noon when the Virtual Queue enrollment begins, open the Virtual Queue section for World of Color - ONE in the app.Distribution for the complimentary Virtual Queue will begin at 12:00 PM noon, daily (subject to availability), and is available for guests who have entered Disney California Adventure park for the day OR have entered Disneyland park with a Park Hopper ticket.And both instantaneous marginal effects (table and graph) doesn't seems to match predicted values rate of change. ![]()
|